Intravenous catheter-related adverse events exceed drug-related adverse events in outpatient parenteral antimicrobial therapy

760Piperacillin/Tazobactam-Induced Adverse Drug Events in Pediatric Patients on Outpatient Parenteral Antimicrobial Therapy (OPAT)

Background. Piperacillin/tazobactam is an ureidopenicillin (piperacillin) combined with a ß-lactamase inhibitor (tazobactam). We have noted an increased rate of suspected piperacillin/tazobactam-related adverse drug events (ADEs) compared to other antibiotics in patients on Outpatient Parenteral Antimicrobial Therapy (OPAT). We sought to compare ADEs in patients who received piperacillin/tazoba...

Pharmacogenetics to predict drug-related adverse events.

Identification of reliable markers to predict drug-related adverse events (DRAEs) is an important goal of the pharmaceutical industry and others within the healthcare community. We have used genetic polymorphisms, including the most frequent source of variation (single nucleotide polymorphisms, SNPs) in the human genome, in pharmacogenetic approaches designed to predict DRAEs. Three studies exe...

HIV-related TB and adverse drug events.

Automatic Detection of Spironolactone - Related Adverse Drug Events

Due to increasing reports of spironolactone associated life-threatening hyperkalemia, we implemented a rule in our automated event detection system to monitor serum potassium results in patients receiving spironolactone. In 2004, 419 (10.49%) of 3995 admissions at 3 BJC HealthCare hospitals were identified as having hyperkalemia while on spironolactone. For a 9-month period in one facility, 33 ...

Opioid-related adverse drug events: do parents recognize the signals?

OBJECTIVES Evidence of unrelieved childhood pain, adverse drug events (ADE), and deaths suggest that parents may inadequately respond to pain and opioid-related ADE signals. This study examined parents' recognition and response to pain and ADE signals using both dynamic hypothetical scenarios and real at-home opioid decisions. MATERIALS AND METHODS A total of 514 parents whose children requir...